Tsotliotl, the ancient Mexican god of vampires has eaten the hearts of humans for untold millennium.
Ramona, a Tarahumara Apache, is chosen as the next sacrifice, but when she escapes taking with her the god's sacred sacrificial knife, Tsotliotl demands they both be recovered at any cost.
Hunted through the Sonoran mountains by two ancient Native American vampires, a horde of starving ghouls, and a greedy banker and his mercenaries, Ramona seeks help from some unlikely heroes, Mike and his boozing, bootleggin’ Gramps.
Now it's up to Mike and Gramps to help save the woman from being sacrificed so the next Cleansing won't destroy the world.
