Private Eye DB and his ghost partner Jesse from Eye Spy are back, and Jesse is dealing with Gwen, the ghost of a little girl. The problem with dealing with ghosts is that they can't pay, and that they make the police a little crazy. So when DB's new informant, the medium Yanya has a fit about the cops, and DB and Jesse's love life, DB knows this case is going to be nothing but trouble.
DB and Jesse have their own problems to deal with, but they also have to figure out who killed Gwen, and try to keep the killer from harming anyone else. Can they solve the case and try to find a way for a man and a ghost to have a life together?